Merotelic kinetochore attachment
Web29 mrt. 2005 · Merotelic kinetochore attachment is a major source of aneuploidy in mammalian tissue cells in culture. Mammalian kinetochores typically have binding sites … Web19 jul. 2024 · When a cell starts to divide, it forms a spindle, a micro-machine made of microtubules, which separates the duplicated chromosomes. The attachment of microtubules to chromosomes is mediated by kinetochores, protein complexes on the chromosome. Spindle microtubules can be divided into three major classes: kinetochore …
Merotelic kinetochore attachment
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WebThe process of chromosome congression and alignment is at the core of mitotic fidelity. In this review, we discuss distinct spatial routes that the chromosomes take to align during prometaphase, which are characterized by distinct biomolecular requirements. Peripheral polar chromosomes are an intriguing case as their alignment depends on the activity of … WebNational Center for Biotechnology Information
Web23 mei 2024 · Kinetochores are multi-protein complexes that power chromosome movements by tracking microtubules plus-ends in the mitotic spindle. Human … Web1 jul. 2007 · Merotelic kinetochore orientation is a kinetochore-microtubule mis-attachment in which a single kinetochore binds microtubules to both spindle poles, rather than just one. …
Web29 mrt. 2005 · Merotelic kinetochore attachment is a major source of aneuploidy in mammalian tissue cells in culture. Mammalian kinetochores typically have binding sites for about 20–25 kinetochore microtubules. In prometaphase, kinetochores become merotelic if they attach to microtubules from opposite poles rather than to just one pole as normally … Web1 mrt. 2013 · Summary. If uncorrected, merotelic kinetochore attachments can induce mis-segregated chromosomes in anaphase. We show that checkpoint kinase 1 (Chk1) protects vertebrate cells against merotelic attachments and lagging chromosomes and is required for correction of merotelic attachments during a prolonged metaphase. Decreased Chk1 …
WebRecent studies showing that merotelic kinetochore attachment represents a major mechanism of aneuploidy in mitotic cells and is the primary mechanism of chromosomal …
Web1 jul. 2007 · Merotelic kinetochore orientation is a kinetochore-microtubule mis-attachment in which a single kinetochore binds microtubules to both spindle poles, rather than just one. Merotelic attachments occur frequently in early mitosis and can induce anaphase lagging chromosomes and aneuploidy if not corrected before anaphase onset. hung drawn and quartered pub menuWeb15 okt. 2003 · Merotelic kinetochore orientation is an error that occurs when a single kinetochore becomes attached to microtubules from two spindle poles rather than just … hung drawn and quartered pub ec3WebMitotic kinetochores are initially captured by dynamic microtubules via a ‘search-and-capture’ mechanism. The microtubule motor, dynein, is critical for kinetochore capture as it has been shown to transport microtubule-attached chromosomes towards the spindle pole during early mitosis. The microtubule-binding Ndc80 complex that is recruited to … hung drawn and quartered processWebMerotelic attachment — one sister kinetochore simultaneously attaches to microtubules extending from both spindle poles. The figure is adapted from a figure in Tanaka et al. (2005b) Source ... hung drawn and quartered ravenWeb1 dec. 2006 · Merotelic kinetochore attachment (in which a kinetochore is attached to MTs emanating from both spindle poles) is a major cause of anaphase lagging chromosomes and aneuploidy in mammalian tissue cells ( Cimini et al., 2001 ). hung drawn and quartered stepsWebMerotelic kinetochore attachment (in which a kinetochore is at-tached to MTs emanating from both spindle poles) is a major cause of anaphase lagging chromosomes and Cell 127, 969–982, December 1, 2006 ª2006 Elsevier Inc. 969. aneuploidy in mammalian tissue cells (Cimini et al., 2001). hung drawn and quartered tower hillWeb7 jun. 2009 · Arrow indicates a lagging chromosome caused by merotelic attachment, in which microtubules emanating from both poles attach to a single kinetochore (inset: microtubules, white; centromere red). hung drawn and quoted