Klf5 phosphorylation
WebMar 8, 2011 · Phosphorylation of HDAC2 switches its interaction preference from RAR to Klf5, and thus promotes Klf5 deacetylation. Deacetylated Klf5 then dissociates from the p21 promoter, and the consequent loss of Klf5-mediated repression further facilitates RAR agonist-stimulated p21 expression. WebDec 6, 2024 · Furthermore, we detected the levels of klf5 phosphorylation, suggesting klf5 phosphorylation level in HFD group was lower than HFD+RSV group. In parallel, in HEK293 cells, we also observed that HG (25 mmol/L) enhanced the interaction of klf5 with c-Myc and klf5 dephosphorylation, which were reversed by treatment with inhibitor LY294002 and RSV.
Klf5 phosphorylation
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WebJul 12, 2024 · These results indicate that LFU and microbubbles combined with simvastatin downregulates the expression of YAP and RHAMM, upregulates LATS1 expression and promotes the phosphorylation of YAP in MCF-7 cells. KLF5, a downstream protein of YAP, had the lowest expression in the UM+SIM group (Fig. 4A). WebHDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs. Abnormal …
WebApr 8, 2024 · Lys32, 52, 232 and 252 sites of KLF4 protein were the main sites involved in the degradation; Ser132 and Ser254 were the phosphorylation sites that might be associated with KLF4 transcriptional ... WebDec 28, 2009 · For this, the phosphorylation status of KLF5 was tested via cross-immunoprecipitation using anti-phospho-Ser and anti-KLF5 antibodies. As shown in Figure 3A, Ang II effectively increased the...
WebDec 10, 2013 · Phosphorylation of KLF5 on serine 406 also enhances interaction with unliganded RARα, which binds to the first zinc finger of the KLF5 DBD, to activate downstream target genes 90, 93. RAR agonists are thought to act via two mechanisms to disrupt the interaction between KLF5 and RARα and subsequently inhibit VSMC … WebNov 15, 2016 · Phosphorylation of KLF5 by PKC enhances the transcriptional activities of KLF5 by promoting its interaction with CREB binding protein . In addition, E3 ubiquitin ligase FBW7, a tumor suppressor, interacts with KLF5 for ubiquitination and degradation [11,12]. Despite understanding of KLF5’s role and its activity regulation in cardiovascular ...
WebDownload scientific diagram Role of AMPK/mTOR pathway in morusin-induced autophagy in non-small cell lung cancer cells. Cells were treated with morusin (20 μM) at various time periods. (A) The ...
Web6.1 Phosphorylation. KLF5 has been shown to be phosphorylated by protein kinase C (PKC) at S153, which upregulates its transactivation activities by enhancing the interaction … オリオン座 右下 星WebSRSF1 promotes vascular smooth muscle cell proliferation through a Δ133p53/EGR1/KLF5 pathway. Nat Commun. 2024; 8: 16016 ( 影响因子 14.919 ) Guo J, Xie N, Li G, Zhang Y （张岩） , Lv F, Guo S, Feng Y, Cao CM, Xiao RP. p55γ functional mimetic peptide N24 blocks vascular proliferative disorders. partito anarchicoWebKLF5. 39 In addition, KLF5 activity is regulated in the nucleus by chromatin remodeling factors such as SET, a histone chaperone that inhibits the DNA binding activity of KLF5,43 … オリオン座大星雲WebDec 28, 2009 · KLF5 is a downstream signal of the ERK 1/2 and p38 MAPK pathways, and activates the transcription of cyclin D1 gene via functional interaction with c-Jun in Ang II-induced VSMC proliferation. Keywords: Krüppel-like factor 5, cyclin D1, angiotensin II, proliferation, vascular smooth muscle cells Go to: Introduction オリオン座 撮影WebApr 15, 2003 · GST–KLF5 fusion protein was phosphorylated by 125 mM ATP as described above. After the reactions, the bound and phosphorylated GST–KLF5 was washed with GST pull‐down buffer (20 mM HEPES, pH 7.5, 0.1 mM EDTA, 75 mM KCl, 2.5 mM MgCl 2, 0.05% NP‐40) three times. partito basta tasseWebKrüppel-like factor 5 (KLF5) is an oncogenic factor that is highly expressed in basal-like breast cancer (BLBC) and promotes cell proliferation, survival, migration, stemness, and tumor growth; however, its posttranslational modifications are poorly defined. partito alternativaWebOct 11, 2024 · KLF5/BTEB2 is an essential transcription factor that causes not only smooth muscle phenotypic modulation but also cardiac hypertrophy and fibrosis; KLF5 has a role … partito andreotti