WebIC50 cisplatin concentration (mM) Source publication Lifeguard inhibition of Fas-mediated apoptosis: A possible mechanism for explaining the cisplatin resistance of triple … WebDrug: Cisplatin - Cancerrxgene - Genomics of Drug Sensitivity in Cancer Genomics of Drug Sensitivity in Cancer Compound: Cisplatin Drug Target: DNA crosslinker Drug Target … STR profiles of cell lines Cell line authentication. Concerns around the … The IC50 and AUC are estimated using a non-linear mixed effect model fitting a … Users have a non-exclusive, non-transferable right to use data files for …
Drug: Cisplatin - Cancerrxgene - Genomics of Drug Sensitivity in …
WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying … WebJun 15, 2024 · Methods: In this study, real-time quantitative PCR (RT-qPCR) and Western blotting (WB) were performed for detecting the expressions of miR-133b, fibroblast growth factor receptor 1 (FGFR1), and Wingless/Integrated (Wnt)-β-catenin pathway markers (Wnt1, β-catenin, nuclear-β-catenin, p-GSK-3β, GSK-3β, cyclinD1, and FOXQ1). iis maximum worker processes 0
Cisplatin (Intravenous Route) Side Effects - Mayo Clinic
WebAug 27, 2024 · The combination of sodium butyrate with cisplatin decreased the IC50 value of cisplatin and attenuated the cytotoxic effect of cisplatin on the normal cells. Accordingly, we selected SGC-7901 cells and HGC-27 cells, which showed better sensitivities to sodium butyrate to perform the subsequent experiments. WebThe DDP at a concentration of IC50 (AGS/DDP cells, 71.34 μM; MKN45/DDP cells, 61.28 μM) was used for further experiments. Bax and Bcl-2 are biomarkers of apoptosis. As illustrated in Figure 2E , the protein expression of Bax was remarkably elevated, while Bcl-2 was declined in AGS/DDP and MKN45/DDP cells following sh-HCG11 transfection or … WebOverexpressing miR-515-5p markedly reduced cisplatin and 5-Fu IC50 values in HK-1/CDDP and CNE-1/CDDP cells, while IL-25 transfection was sufficient to reverse this phenotype (Figure 4E and F). As such, our data demonstrate that circNRIP1 enhances 5-Fu and cisplatin resistance in NPC cells at least in part via sequestering miR-515-5p and ... iis maxwell nichelino